| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379069 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
High-throughput screening of the P&GP corporate repository against several protein tyrosine phosphatases identified the sulfamic acid moiety as potential phosphotyrosine mimetic. Incorporation of the sulfamic acid onto a 1,2,3,4-tetrahydroisoquinoline scaffold provided a promising starting point for PTP1B inhibitor design.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sean R. Klopfenstein, Artem G. Evdokimov, Anny-Odile Colson, Neil T. Fairweather, Jeffrey J. Neuman, Matthew B. Maier, Jeffrey L. Gray, Gina S. Gerwe, George E. Stake, Brian W. Howard, Julie A. Farmer, Matthew E. Pokross, Thomas R. Downs,