Structural modifications of the cannabinoid side chain towards C3-aryl and 1′,1′-cycloalkyl-1′-cyano cannabinoids

The compounds reported in this study are Δ8-THC analogues in which the C3 five-carbon linear side chain of Δ8-THC was replaced with aryl and 1′,1′-cycloalkyl substituents. Of the compounds described here analogues 2d (CB1, Ki = 11.7 nM. CB2, Ki = 9.39 nM) and 2f (CB1, Ki = 8.26 nM. CB2, Ki = 3.86 nM) exhibited enhanced binding affinities for CB1 and CB2, exceeding that of Δ8-THC. Efficient procedures for the synthesis of these novel cannabinoid analogues are described.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide