| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379079 | Bioorganic & Medicinal Chemistry Letters | 2006 | 7 Pages |
Abstract
Depeptidization efforts of the P3–P2 region of P3 capped α-ketoamide inhibitor of HCV NS3 serine protease 1 are reported. We clearly established that N-methylation of the P2 nitrogen and modification of the P2′ carboxylic acid terminus were essential for activity in the replicon assay.
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Authors
Stéphane L. Bogen, Sumei Ruan, Rong Liu, Sony Agrawal, John Pichardo, Andrew Prongay, Bahige Baroudy, Anil K. Saksena, Viyyoor Girijavallabhan, F. George Njoroge,