| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379081 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A series of novel C-5 substituted anilinoquinazolines, selected on the basis of docking experiments and overlays with ATP in the active site of EGFR tyrosine kinase, have been prepared and found to be potent inhibitors. In vivo pharmacokinetics and disease model activity are discussed.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Peter Ballard, Robert H. Bradbury, Craig S. Harris, Laurent F.A. Hennequin, Mark Hickinson, Paul D. Johnson, Jason G. Kettle, Teresa Klinowska, Andrew G. Leach, Remy Morgentin, Martin Pass, Donald J. Ogilvie, Annie Olivier, Nicolas Warin,