| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379084 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A δ-carboline derivative was covalently coupled to a 7 mer oligonucleotide at its 5â²- or 3â²-end. The stability of triplexes formed from the conjugates and a double-helical target was studied by UV melting experiments. Compared to the unmodified control triple helices, triplexes with the conjugate exhibit a significantly higher stability. However, the degree of stabilization depends on the particular triplex structure formed.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nina TodoroviÄ, Nguyen Thi Bich Phuong, Peter Langer, Klaus Weisz,