Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1379086 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Natural product hedychilactone A (3) has been synthesized from (+)-sclareolide by an efficient route. Two of the synthetic intermediates, 10 and 12, have shown strong growth inhibition effects against five cancer cell lines, human umbilical vein endothelial cell (HUVEC) and nitric oxide (NO) production. In particular, compound 15 showed selective inhibition activity against HUVEC growth without any cytotoxicity among tested cancer cell lines.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sangtae Oh, In Howa Jeong, Woon-Seob Shin, Qian Wang, Seokjoon Lee,