| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379087 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Three water-soluble DNA cross-linking phenol quaternary ammonium derivatives 3, 4, and 5 could inhibit the transcription in vitro by photoactivation. DNA interstrand cross-linking action might be the key factor to inhibit transcription by these compounds. Further tumor cell apoptosis was observed by flow cytometry it indicated that cross-linking agent 5 could significantly induce the late apoptosis of tumor cells.
Graphical abstractThree water-soluble DNA cross-linking phenol quaternary ammonium derivatives 3, 4, and 5 could inhibit the transcription in vitro by photoactivation. DNA interstrand cross-linking action might be the key factor to inhibit transcription by these compounds. Further tumor cell apoptosis was observed by flow cytometry and it indicated that cross-linking agent 5 could significantly induce the late apoptosis of tumor cells.Figure optionsDownload full-size imageDownload as PowerPoint slide
