| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379094 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
A series of indole-O-glucosides and C-glucosides was synthesized and evaluated in SGLT1 and SGLT2 cell-based functional assays. Compounds 2a and 2o were identified as potent SGLT2 inhibitors and screened in ZDF rats.
Graphical abstractA series of indole-O-glucosides was synthesized and evaluated in SGLT1 and SGLT2 cell-based functional assays. Compounds 2a and 2o were identified as potent SGLT2 inhibitors and screened in ZDF rats.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xiaoyan Zhang, Maud Urbanski, Mona Patel, Geoffrey G. Cox, Roxanne E. Zeck, Haiyan Bian, Bruce R. Conway, Mary Pat Beavers, Philip J. Rybczynski, Keith T. Demarest,