Synthesis and SAR of substituted tetrahydrocarbazole derivatives as new NPY-1 antagonists

The SAR of a new series of tetrahydrocarbazole derivatives is described: the appropriate decoration of this template led to the identification of a new class of NPY-1 antagonists showing good in vitro potency and a promising in vivo pharmacokinetic profile in rat.

Graphical abstractThe synthesis and the SAR of new series of NPY-1 antagonists are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide