Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivatives: Dual agonists for human peroxisome proliferator-activated receptor α and δ

Optically active (S)-2-ethylphenylpropanoic acid derivatives, dual agonists for human peroxisome proliferator-activated receptor (PPAR) α and δ, were efficiently prepared by using Evan’s chiral oxazolidinone technique and reductive amide N-alkylation as key steps.

Graphical abstractOptically active (S)-2-ethylphenylpropanoic acid derivatives, dual agonists for human peroxisome proliferator-activated receptor (PPAR) α and δ, were efficiently prepared.Figure optionsDownload full-size imageDownload as PowerPoint slide