Two methylene groups in phospholipids distinguish between apoptosis and necrosis for tumor cells

High inhibitory effects of hybrid liposomes (HL) themselves composed of DMPC/10 mol % C12(EO)23 on the growth of HL-60 cells were obtained without any drug. Induction of apoptosis was obtained by the HL of DMPC/10 mol % C12(EO)23. On the other hand, necrosis was observed for the HL of DLPC/10 mol % C12(EO)23. In the case of DPPC/10 mol % C12(EO)23, neither apoptosis nor necrosis was observed.

Graphical abstractIt was found that two methylene groups in phospholipids having the same head group could clearly distinguish between apoptosis and necrosis for human leukemia cells.Figure optionsDownload full-size imageDownload as PowerPoint slide