Article ID Journal Published Year Pages File Type
1379223 Bioorganic & Medicinal Chemistry Letters 2006 4 Pages PDF
Abstract

A novel unusual 17-carbon diterpenoid, named (+)-7-deoxynimbidiol, was isolated from the stalks of Celastrus hypoleucus (Oliv.) Warb. Its racemate and derivatives were synthesized, and the inhibitory activities of these compounds against four cultured human-tumor cell lines were evaluated. The structure–activity relationship was discussed.

Graphical abstractA novel unusual 17-carbon diterpenoid, named (+)-7-deoxynimbidiol, was isolated from the stalks of Celastrus hypoleucus (Oliv.) Warb., and its racemate and derivatives were synthesized. When their anti-tumor activities were evaluated, compounds 2, 11, and 2b were found to have potency against the cultured human-tumor cell lines HeLa, A549, CNE, and MCF in vitro. The SAR (structure–activity relationship) was discussed.Figure optionsDownload full-size imageDownload as PowerPoint slide

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Physical Sciences and Engineering Chemistry Organic Chemistry
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