| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379227 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A strategy of dimethylamino alkyldiimide conjugated with an intercalator of naphthalimide for hydrolysis of DNA was suggested and evaluated. 4 can hydrolyze 4 kb plasmid DNA into 2 kb fragments with GC and GG selectivity, which represents a novel example of sequence- or site-selective metal-free DNA artificial nuclease. Results also show it could hydrolyze RNA efficiently.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Qing Yang, Jianqiang Xu, Yuanshe Sun, Zhigang Li, Yonggang Li, Xuhong Qian,