| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379238 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
The transcription factor nuclear factor-κB (NF-κB) is a key component in the onset of inflammation. We describe here a series of 4-hydroxyphenyl sulfonamide estrogen receptor (ER) ligands that selectively inhibit NK-κB transcriptional activity but are devoid of conventional estrogenic activity.
Graphical abstractWe describe here a series of 4-hydroxyphenyl sulfonamide estrogen receptor (ER) ligands that selectively inhibit NF-κB transcriptional activity but are devoid of conventional estrogenic activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Joseph P. Sabatucci, Mark A. Ashwell, Eugene Trybulski, Mary-Margaret O’Donnell, William J. Moore, Douglas C. Harnish, Christopher C. Chadwick,