| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379248 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Aplysamine-1 (1), a marine natural product, was synthesized and screened for in vitro activity at the human and rat histamine H3 receptors. Aplysamine-1 (1) was found to possess a high binding affinity for the human H3 receptor (Ki = 30 ± 4 nM). Synthetic analogs of 1, including des-bromoaplysamine-1 (10) and dimethyl-{2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-ethyl}-amine (13), were potent H3 antagonists.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Devin M. Swanson, Sandy J. Wilson, Jamin D. Boggs, Wei Xiao, Richard Apodaca, Ann J. Barbier, Timothy W. Lovenberg, Nicholas I. Carruthers,