| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379249 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
To enable studies to elucidate the intracellular processing and targeting of the potent cytostatic/apoptotic anticancer natural products phorboxazoles A and B, a fluorescent derivative has been developed. This involved the total syntheses of the terminal alkyne 33-O-Me-45,46-dehydrobromophorboxazole A (MDHBPA) and a terminal vinyl iodide derivative of the blue fluorescent dye N,N,-dimethyl-7-aminocoumarin (DMC). Sonogashira coupling of these partners provided enyne DMC–MDHBPA in high yield.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Jiehao Chen, Lu Ying, T. Matthew Hansen, Mary M. Engler, Chi Sing Lee, James J. La Clair, Craig J. Forsyth,