| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379252 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A series of 2-alkoxydihydrocinnamates were synthesized as PPARγ and PPARα dual agonists. In vitro studies in cell model showed that these compounds were efficacious. Compound 1g was found to be a potent PPARα/γ dual agonist and will be further evaluated for the treatment of type II diabetes.
Graphical abstractA series of 2-alkoxydihydrocinnamates as PPARγ and PPARα dual agonists with substituted biphenyl tailpiece were synthesized and tested for their functional activity in vitro.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ying Lu, Zongru Guo, Yanshen Guo, Jun Feng, Fengming Chu,