| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379254 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
Helicases form an attractive protein family for drug discovery because they are involved in various human diseases. In this report, we show that it is possible to inhibit both the ATPase and the helicase activities of a DNA helicase with dibenzothiepins that bind at its nucleic acid binding site. These results suggest a drug discovery strategy to inhibit DNA helicases.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sandy Dubaele, Wolfang Jahnke, Joseph Schoepfer, Jean Fuchs, Patrick Chène,