| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379256 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A novel series of 2-anilino-3-phenylsulfonyl-6-methylpyridines was synthesized and evaluated as corticotropin-releasing factor receptor ligands. Structure–activity relationship studies focused primarily on optimization of the 3-phenylsulfonyl group. Compounds within this series were identified which showed potent binding affinity for the CRF1 receptor. Selected compounds were examined in a rat pharmacokinetic study and were found to have oral bioavailabilities ranging from 16 to 35%.
Graphical abstractA novel series of 2-anilino-3-phenylsulfonyl-6-methylpyridines was synthesized and evaluated as corticotropin-releasing factor receptor ligands.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Richard A. Hartz, Argyrios G. Arvanitis, Charles Arnold, Joseph P. Rescinito, Kimberly L. Hung, Ge Zhang, Harvey Wong, David R. Langley, Paul J. Gilligan, George L. Trainor,