| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379259 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
Two new dihydrocoumarin derivatives, compounds 1 and 2, were isolated from Aloe vera. Their structures were determined by X-ray crystallographic diffraction analysis and extensive 1D, 2D NMR spectroscopic data. Both of them evidently showed antioxidant activity against superoxide and hydroxyl radicals. Only 1 obviously exhibited immunomodulatory activity in relation to increasing the phagocytic activity and stimulating the production of superoxide anions in the oxygen respiratory burst of rat peritoneal macrophages.
Graphical abstractOnly the isolated compound 1 is probably beneficial in regulating the ROS levels by scavenging ROS and promoting immunomodulatory activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xiu-feng Zhang, Hong-mei Wang, Yuan-li Song, Li-hua Nie, Lan-fen Wang, Bin Liu, Ping-ping Shen, Yang Liu,