Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1379261 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A Hit-to-Lead optimisation programme was carried out on a high throughput screening hit, the thiazolopyrimidine 1, resulting in the discovery of the potent, orally bioavailable CXCR2 antagonist 29.
Graphical abstractA Hit-to-Lead optimisation programme was carried out on a high throughput screening hit, the thiazolopyrimidine 1, resulting in the discovery of the potent, orally bioavailable CXCR2 antagonist 29.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Andrew Baxter, Anne Cooper, Elizabeth Kinchin, Kerry Moakes, John Unitt, Alan Wallace,