| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379263 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A series of synthetic 2-morpholinochromones have been evaluated as inhibitors of platelet phosphodiesterase, PDE3A. While previous assertions about the anti-PDE3 activity of this class have been confirmed, in some cases the reported anti-platelet activities clearly derive from a non-PDE3 regulated mechanism. The potential utility of 2-morpholinochromones either as PDE3 inhibitors and/or anti-thrombotic agents thus remains only poorly examined.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Belinda M. Abbott, Philip E. Thompson,