| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379267 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
A novel series of histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine template displaying low CYP2D6 and CYP3A4 inhibitory profiles has been identified. Structural features responsible for the reduction of P450 activity, a typical liability of 4-substituted imidazoles, have been established.
Graphical abstractA novel series of histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine template displaying low CYP2D6 and CYP3A4 inhibitory profiles has been identifiedFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists](/preview/png/1379267.png "First Page Preview: Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists")
Authors
Michael Berlin, Pauline C. Ting, Wayne D. Vaccaro, Robert Aslanian, Kevin D. McCormick, Joe F. Lee, Margaret M. Albanese, Mwangi W. Mutahi, John J. Piwinski, Neng-Yang Shih, Luli Duguma, Daniel M. Solomon, Wei Zhou, Rosy Sher, Leonard Favreau,