| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379275 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
Prototypical thrombin inhibitors were synthesized based on a trisubstituted phenol as a core motif. A naphthylsulfonamide analogue showed excellent antithrombin activity. An X-ray co-crystal structure showed the expected interactions.
Related Topics
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Authors
Stephen Hanessian, Eric Therrien, Willem A.L. van Otterlo, Malken Bayrakdarian, Ingemar Nilsson, Ola Fjellström, Yafeng Xue,