| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379282 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A series of novel five-membered urea derivatives as potent NK1 receptor antagonists is described. The effects of substitution of a 4-fluoro group at the phenyl ring and the introduction of an α-methyl group at the benzylic position to improve potency and duration of in vivo activity are discussed. Several compounds with high affinity and sustained in vivo activity were identified.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ho-Jane Shue, Xiao Chen, John H. Schwerdt, Sunil Paliwal, David J. Blythin, Ling Lin, Danlin Gu, Cheng Wang, Gregory A. Reichard, Hongwu Wang, John J. Piwinski, Ruth A. Duffy, Jean E. Lachowicz, Vicki L. Coffin, Amin A. Nomeir, Cynthia A. Morgan,