| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379383 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
The first synthesis of the cyclopentapeptide family 18 chitinase inhibitor argifin has been achieved by a combination of solid phase and solution chemistry. Synthetic argifin is a nanomolar inhibitor of chitinase B1 from Aspergillus fumigatus and the high-resolution X-ray structure of the synthesized material in complex with the same enzyme is identical to that previously obtained for the natural product.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mark J. Dixon, Ole A. Andersen, Daan M.F. van Aalten, Ian M. Eggleston,