Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1379385 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
Potent and selective ligands of the α7 nicotinic acetylcholine receptor are required to understand the pharmacological effect of α7 activation. A common cross-reactivity occurs with serotonergic 5-HT3 receptors with which α7 receptors have a high sequence homology. We demonstrate that certain quinuclidine 3-biaryl carboxamides are high affinity α7 ligands with an excellent binding selectivity over 5-HT3 receptors.
Graphical abstractCertain quinuclidine 3-biarylcarboxamides are high affinity nicotinic α7 ligands with an excellent binding selectivity over the 5-HT3 receptor.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
S. Richard Baker, John Boot, Michael Brunavs, David Dobson, Rachel Green, Lorna Hayhurst, Martine Keenan, Louise Wallace,