Article ID Journal Published Year Pages File Type
1379385 Bioorganic & Medicinal Chemistry Letters 2005 4 Pages PDF
Abstract

Potent and selective ligands of the α7 nicotinic acetylcholine receptor are required to understand the pharmacological effect of α7 activation. A common cross-reactivity occurs with serotonergic 5-HT3 receptors with which α7 receptors have a high sequence homology. We demonstrate that certain quinuclidine 3-biaryl carboxamides are high affinity α7 ligands with an excellent binding selectivity over 5-HT3 receptors.

Graphical abstractCertain quinuclidine 3-biarylcarboxamides are high affinity nicotinic α7 ligands with an excellent binding selectivity over the 5-HT3 receptor.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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