| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379393 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
Cyclohexylglycine amides of various fluorinated pyrrolidines and azetidines were prepared and tested for activity against dipeptidyl peptidase IV and in vivo in the KK mouse model of type 2 diabetes. The tetrafluoropyrrolidide, cis-3,4-difluoropyrrolidide and the fluorinated azetidides displayed unexpectedly strong activity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bernard Hulin, Shawn Cabral, Michael G. Lopaze, Maria A. Van Volkenburg, Kim M. Andrews, Janice C. Parker,