| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379397 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A series of 3-anilino-quinoxalinones has been identified as a new class of glycogen phosphorylase inhibitors. The lead compound 1 was identified through high throughput screening as well as through pharmacophore-based electronic screening. Modifications were made to the scaffold of 1 to produce novel analogues, some of which are 25 times more potent than the lead compound.
Graphical abstractA series of 3-anilino-quinoxalinones has been identified as a new class of glycogen phosphorylase inhibitors.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Joseph Dudash Jr., Yongzheng Zhang, John B. Moore, Richard Look, Yin Liang, Mary Pat Beavers, Bruce R. Conway, Philip J. Rybczynski, Keith T. Demarest,