Article ID Journal Published Year Pages File Type
1379407 Bioorganic & Medicinal Chemistry Letters 2005 5 Pages PDF
Abstract

Herein is described a new class of selective σ1 ligands consisting of tetrahydroisoquinoline-hydantoin (Tic-hydantoin) derivatives. Compound 3a has high affinity (IC50 = 16 nM) for the σ1 receptor and is selective in a large panel of therapeutic targets. This first study presents structural changes around the Tic-hydantoin core, leading to a Tic-hydantoin analogue with a higher σ1 affinity (IC50 ≈ 1 nM).

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Physical Sciences and Engineering Chemistry Organic Chemistry
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