| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379408 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
Several non-amidino S1 derivatives of the 1,2-diaminobenzene-based scaffold (4) were synthesized and evaluated for their ability to bind to the active site and inhibit the human protease factor Xa. A subset of these compounds were also evaluated for their anticoagulant effects in human plasma as measured by prothrombin time (PT).
Graphical abstractSeveral non-amidino S1 derivatives of the 1,2-diaminobenzene-based scaffold were synthesized and evaluated for their ability to inhibit the human protease factor Xa.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Jeffry B. Franciskovich, John J. Masters, Jennifer M. Tinsley, Trelia J. Craft, Larry L. Froelich, Donetta S. Gifford-Moore, Valentine J. Klimkowski, Jeffrey K. Smallwood, Gerald F. Smith, Tommy Smith, Richard R. Towner, Leonard C. Weir,