Article ID Journal Published Year Pages File Type
1379410 Bioorganic & Medicinal Chemistry Letters 2005 4 Pages PDF
Abstract

A biotinylated derivative of the anti-tumor agent camptothecin (CPT) was synthesized and used in a phage display assay to identify drug-binding sequences. After three rounds of selection using C20-biotinylated CPT (CPT-20-B) as bait, a CPT-20-B-binding sequence, NSSQSARR, was identified.

Graphical abstractSynthesis of CPT-20-B and peptide screening by T7 phage display method have been reported.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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