Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1379410 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A biotinylated derivative of the anti-tumor agent camptothecin (CPT) was synthesized and used in a phage display assay to identify drug-binding sequences. After three rounds of selection using C20-biotinylated CPT (CPT-20-B) as bait, a CPT-20-B-binding sequence, NSSQSARR, was identified.
Graphical abstractSynthesis of CPT-20-B and peptide screening by T7 phage display method have been reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yoichi Takakusagi, Keisuke Ohta, Kouji Kuramochi, Kengo Morohashi, Susumu Kobayashi, Kengo Sakaguchi, Fumio Sugawara,