Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1379411 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
An analysis of non-biotinylated camptothecin (CPT) binding to the C-20-biotinylated CPT binding peptide NSSQSARR was carried out using two methods, quartz-crystal microbalance (QCM) and surface plasmon resonance (SPR). The peptide was immobilized peptide on a sensor chip and showed a dissociation constant (KD) of approximately 0.1 μM against CPT in QCM and SPR experiments.
Graphical abstractAn analysis of non-biotinylated campotothecin (CPT) binding to the C-20-biotinylated CPT binding peptide was carried out using QCM and SPR.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yoichi Takakusagi, Susumu Kobayashi, Fumio Sugawara,