Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1379413 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
Chalcones can exist as Z- or E-isomers and it is generally anticipated that both isomers are equipotent. In order to determine the active isomer of anti-plasmodial chalcones a series of analogues locked in the Z- or the E-form were prepared and evaluated for their anti-plasmodial activity. It was shown that the Z-locked analogue was nearly inactive, whereas the E-locked analogues were equipotent to the parent chalcones, indicating that the E-isomer is the active conformation.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mogens Larsen, Hasse Kromann, Arsalan Kharazmi, Simon Feldbæk Nielsen,