Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1379572 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
We have shown that a 4-phenyl-1,2,3,6-tetrahydropyridine fragment plays an important role in improving inhibitory potency against poly(ADP-ribose) polymerase-1 (PARP-1). Various benzamide analogues linked with this fragment via alkyl spacers have been prepared and evaluated. As a result, some of them have been found to be highly potent PARP-1 inhibitors.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Junya Ishida, Kouji Hattori, Hirofumi Yamamoto, Akinori Iwashita, Kayoko Mihara, Nobuya Matsuoka,