Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1379573 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
Starting from a 6,7-substituted quinazoline lead 4, optimisation of 5-substituted quinazolines containing an extended aniline motif led to potent and selective inhibitors of erbB2 receptor tyrosine kinase, and a representative compound 12a inhibited tumour growth in a mouse xenograft model.
Graphical abstractStarting from a 6,7-substituted quinazoline lead 4, optimisation of 5-substituted quinazolines containing an extended aniline motif led to potent and selective inhibitors of erbB2 receptor tyrosine kinase, and a representative compound 12a inhibited tumour growth in a mouse xenograft model.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
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Organic Chemistry
Authors
Peter Ballard, Robert H. Bradbury, Laurent F.A. Hennequin, D. Mark Hickinson, Paul D. Johnson, Jason G. Kettle, Teresa Klinowska, Remy Morgentin, Donald J. Ogilvie, Annie Olivier,