Aqua mediated synthesis of substituted 2-amino-4H-chromenes and in vitro study as antibacterial agents

A simple, clean, environmentally benign route to the synthesis of 2-amino-chromenes is described using K2CO3 as a green catalyst in water under microwave irradiation. This implies a convenient route avoiding the usage of hazardous organic solvents and organic bases. This technique requires only water in both the reaction step and workup, thus rendering the whole procedure into a truly ecofriendly green protocol. All the synthesized compounds were shown to possess antibacterial activity as tested in vitro against standard strains of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus.

Graphical abstractSubstituted 2-amino-4H-chromenes have been efficiently synthesized in aqueous K2CO3 and their in vitro antibacterial activities were evaluated against standard strains of bacteria using Broth Microdilution MIC method.Figure optionsDownload full-size imageDownload as PowerPoint slide