3-(2-Aminoethyl)pyridine analogs as α4β2 nicotinic cholinergic receptor ligands

An examination of several 3-(2-aminoethyl)pyridine analogs suggests that they likely orient at α4β2 nicotinic cholinergic receptors in a different fashion than their correspondingly substituted nicotine analogs.

Graphical abstractAn examination of several 3-(2-aminoethyl)pyridine analogs 2 (with Ki values ranging from 18 to >10,000 nM) and comparison with their structurally related nicotine analogs 1 suggest that the two series likely bind at nicotinic cholinergic receptors in a different fashion.Figure optionsDownload full-size imageDownload as PowerPoint slide