| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379596 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
Ligands possessing dual vitamin D3-agonistic (estimated as HL-60 monocytic cell differentiation induction) and androgen-antagonistic (estimated as testosterone-induced SC-3 cell growth inhibition) activities with various activity spectra were prepared based on a substituted bis-phenylmethane skeleton. Some of them were revealed to be potent androgen antagonists with a nonsecosteroidal vitamin D3 skeleton.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shinnosuke Hosoda, Aya Tanatani, Ken-ichi Wakabayashi, Yusuke Nakano, Hiroyuki Miyachi, Kazuo Nagasawa, Yuichi Hashimoto,