| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379597 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
The designed cytosine–carbohydrate hybrid molecule selectively recognized and stabilized the bulged duplex DNA possessing the complementary bulged DNA base, guanine, while the nucleotide base itself did not exhibit any such ability. It was also found that the assistance of the carbohydrate to stabilize the interaction between the nucleotide base and the complementally bulge DNA base is very helpful for the selective recognition and stabilization of the single-bulged duplex DNA.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yusuke Idutsu, Ayaka Sasaki, Shuichi Matsumura, Kazunobu Toshima,