Adamantyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1

Adamantyl triazoles were identified as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). They are active both in in vitro and in in vivo pharmacodynamic models. The synthesis and structure–activity relationships of these inhibitors are presented.

Graphical abstractThe synthesis and biological activity of selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide