| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379606 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
A series of novel 8-piperazinyl-2,3-dihydropyrroloisoquinolines, e.g., compound 22, was prepared showing high affinity and selectivity for 5-HT1A, 5-HT1B and 5-HT1D receptors combined with favourable pharmacokinetic properties.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![8-Piperazinyl-2,3-dihydropyrrolo[3,2-g]isoquinolines: Potent, selective, orally bioavailable 5-HT1 receptor ligands](/preview/png/1379606.png "First Page Preview: 8-Piperazinyl-2,3-dihydropyrrolo[3,2-g]isoquinolines: Potent, selective, orally bioavailable 5-HT1 receptor ligands")
Authors
Tom D. Heightman, Laramie M. Gaster, Sarah L. Pardoe, Jean-Pierre Pilleux, Michael S. Hadley, Derek N. Middlemiss, Gary W. Price, Claire Roberts, Claire M. Scott, Jeannette M. Watson, Laurie J. Gordon, Vicky A. Holland, Jenifer Powles, Graham J. Riley,