Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1379608 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-[18F]fluoro-2-oxo-1, 2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, a new potential positron emission tomography tracer for imaging cancer tyrosine kinase, has been prepared by the nucleophilic substitution of the nitro-precursor N-[2-(diethylamino)ethyl]-5-[(Z)-(5-nitro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide with K18F/Kryptofix 2.2.2 followed by a simple chromatography methodology combined solid-phase extraction with high-performance liquid chromatography purification procedures in 15–25% radiochemical yields.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ji-Quan Wang, Kathy D. Miller, George W. Sledge, Qi-Huang Zheng,