Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1379704 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A series of 4-substituted (benzo[b]thiophene-2-carbonyl)guanidines was synthesized and evaluated for the NHE-1 inhibitory activity and cardioprotective efficacy both in vitro and in vivo. Several analogs exhibited a strong inhibition on NHE-1, and which was generally well correlated with their cardioprotective efficacy. Especially the 4-nitro 20 and cyano 50 compounds excellently improved the cardiac function and reduced infarct size against ischemia/reperfusion injury.
Graphical abstractSynthesis and biological evaluation of 4-substituted (benzo[b]thiophene-2-carbonyl)guanidines as NHE-1 inhibitors are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sunkyung Lee, Hyunsuk Lee, Kyu Yang Yi, Byung Ho Lee, Sung-eun Yoo, Kyunghee Lee, Nam Sook Cho,