Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives

A series of novel (un)substituted benzotriazolyl oxazolidinone derivatives has been synthesized and tested for in vitro antibacterial activities by MIC determination against a panel of susceptible and resistant Gram-positive and Gram-negative microorganisms, some of which are resistant to methicillin and vancomycin. Compounds 20, 21, 24, 29 and 30 from this series were found to be equipotent or more potent than linezolid in vitro.

Graphical abstractOxazolidinone derivatives containing (un)substituted-benzotriazole ring were synthesized and exhibited potent in vitro antibacterial activity against many antibiotic-resistant microbial strains. Several analogues from this series were comparable or more potent than linezolid in vitro.Figure optionsDownload full-size imageDownload as PowerPoint slide