| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379707 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Synthesis of nitrone derivatives of trolox is described. Their biological evaluation was performed in vitro for scavenging different free radicals, inhibiting Fe2+-induced lipid peroxidation, and in vivo in a permanent middle cerebral artery occlusion model in mice. New compounds exert pharmacological activities comparable to or better than those of trolox or nitrone-type reference compounds.
Graphical abstractSynthesis of nitrone derivatives of trolox 2 is described. Their biological evaluation was performed in vitro for scavenging different free radicals, inhibiting Fe2+-induced lipid peroxidation, and in vivo in a permanent middle cerebral artery occlusion model in mice. New compounds 2 exert pharmacological activities comparable to or better than those of trolox or nitrone-type reference compounds.Figure optionsDownload full-size imageDownload as PowerPoint slide
