The synthesis of substituted bipiperidine amide compounds as CCR3 ligands: Antagonists versus agonists

Structure–activity relationship study of bipiperidine amide 1 has identified the reverse bipiperidine amide 4a as a CC chemokine-3 (CCR3) receptor antagonist. Optimization of the structure–activity relationship of compound 4a has resulted in the identification of a CCR3 antagonist 4i as well as a CCR3 agonist 13.

Graphical abstractThe structure–activity relationship of 3-substituted bipiperidine 4a as a CCR3 antagonist has been investigated.Figure optionsDownload full-size imageDownload as PowerPoint slide