| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379710 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
An exploratory series of novel arylbromide and bicyclic chemosensitizers (modulators) against chloroquine-resistant Plasmodium falciparum were designed and synthesized on the basis of a basic chemosensitizing pharmacophore hypothesis in malaria. ortho-Substituted bromo and biphenyl ether compounds displayed the best activity from the series.
Graphical abstractA new series of chemosensitizers against drug resistant and sensitive strains of P. falciparum were designed on the basis of a basic chemosensitizing pharmacophore hypothesis.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Franck Chouteau, David Ramanitrahasimbola, Philippe Rasoanaivo, Kelly Chibale,