Structure–activity relationship of N-methyl-bisindolylmaleimide derivatives as cell death inhibitors

A series of N-methyl-bisindolylmaleimide derivatives was synthesized and evaluated as cell death inhibitors. N-Methyl-2-[1-(3-aminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide (21) was the most potent inhibitor of H2O2-induced necrotic death of human leukemia HL60 cells among them.

Graphical abstractA series of N-methyl-bisindolylmaleimide derivatives was synthesized and evaluated as cell death inhibitors.Figure optionsDownload full-size imageDownload as PowerPoint slide