| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379733 | Bioorganic & Medicinal Chemistry Letters | 2005 | 6 Pages |
Abstract
The syntheses of a series of 2-arylindene-1-ones as potent ligands of ERβ and ERα are described. Several compounds exhibited high potency and moderate selectivity for the ERβ receptor. X-ray and modeling studies were used to understand ligand binding orientation and observed affinity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Robert E. McDevitt, Michael S. Malamas, Eric S. Manas, Rayomand J. Unwalla, Zhang B. Xu, Chris P. Miller, Heather A. Harris,